The host unit at RAF Mildenhall is the 100th Air Refueling Wing (100 ARW), which deploys aircraft for and manages the European Tanker Task Force, a rotational force which provides air refuelling to US and NATO aircraft in the European Theatre. It is the only permanent USAF air refuelling wing in the European theatre, activated at RAF Mildenhall on 1 February 1992. The wing provides the critical air refuelling ‘bridge’ that allows the Expeditionary Air Force to deploy around the globe with the appropriate urgency.

The tactical component of the 100 ARW is the 351st Air Refueling Squadron (351 ARS), flying the Boeing KC-135R Stratotanker.